Author:
Kai Knudsen
Updated:
14 August, 2024
Here you will find recommended therapeutic serum concentrations for a range of medications used in intensive care. The tables present the medications sorted by both generic names and brand names.
Content:
Therapeutic Drug Concentrations
| Drugs | Label Name | Specimen | Reference values in Serum |
|---|---|---|---|
| Amitriptyline | Saroten, Tryptizol | S-: | 300-700 nmol/L |
| Amlodipine | Amlodipin, Norvasc | S-: | 0,025 mg/L |
| Atenolol | Atenolol, Tenormin | S-: | 0,54 mg/L |
| Carbamazepine | Tegretol, Hermolepsin | S-: | 20-40 µmol/L |
| Citalopram | Citalopram, Cipralex. | S-: | 20-800 nmol/L |
| Digoxin | Lanacrist | S-: | <1,4 nmol/L |
| Phenytoin | Epanutin | S-: | 40-80 µmol/L |
| Flecainide | Tambocor | S-: | 0,5-2,0 µmol/L |
| Fluoxetin | Fontex | S-: | 100-1940 nmol/L |
| Gentamicin | Gentamicin, Garamycin | S-: | 1.5-4.0 mg/L 8 hours after administration. |
| Clomipramin | Anafranil | S-: | 550-1300 nmol/L (Clomipramin + desmetylklomipramin) |
| Clonazepam | Iktorivil | S-: | 35-60-(120) µmol/L |
| Litium | Lithionit | S-: | 0,5 -0,8 mmol/L, sometimes 0,9-1,2 mmol/L |
| Lamotrigin | Lamictal | P-: | 12-56 µmol/L |
| Levetiracetam | Keppra | P-: | 35-120 µmol/L |
| Meropenemanhydrat | Meronem | S-: | 8-10 µg/mL |
| Mirtazapin | Mirtazapin, Remeron | S-: | 35-520 nmol/L |
| Olanzapin | Olanzapine, Zyprexa | S-: | 15-300 nmol/L |
| Oxazepam | Oxazepam, Oxascand | S-: | 0,7-4,2 µmol/L. |
| Paracetamol | Alvedon, Panodil, Reliv | S-: | Reference value not detectable. In case of intoxication, sampling, interpretation of test results and treatment should be in accordance with the Poison Information Center's guidelines. |
| Paroxetine | Paroxetine, Seroxat | S-: | 20-600 nmol/L |
| Propranolol | Propranolol, Inderal | S-: | 0,075-0,1 mg/L |
| Quetiapine | Seroquel | S-: | 50-700 nmol/L |
| Risperidon | Risperidone, Risperdal | S-: | 50-150 nmol/L |
| Salicylates | Trombyl, Treo, Magnecyl, Bamyl, Aspirine | S-: | 1,1-2,2 mmol/L (Adults) |
| Sertraline | Sertraline, Seroxat | S-: | 10-525 nmol/L |
| Tacrolimus | Prograf | B-: | 5-20 µg/L |
| Theophylline | Theophylline, Theo-Dur | S-: | 55-110 µmol/L |
| Tobramycin | Nebcin | S-: | The lowest value should not exceed 2 mg/L. In a test taken 1 hour after initiation of administration, the concentration should be at least 4 mg/L and not more than 12 mg/L. |
| Topiramat | Topimax | S-: | 15-60 µmol/L. |
| Valproate | Ergenyl | S-: | 350-700 µmol/L |
| Vancomycine | Vancocin | S-: | The lowest value should not exceed 15 mg/L. Samples taken 1 hour after completion of infusion should not exceed 50 mg/L. |
| Venlafaxine | Efexor | S-: | 50-900 nmol/L |
| Zuclopentixol | Cisordinol | S-: | 7-30 nmol/L |
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