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Coagulation – Hemostatic Drugs and Thrombosis Prophylaxis

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Coagulation Administering thrombolysis and preventing thromboembolisms is common in conditions such as acute coronary syndromes, stroke, and other thromboembolic diseases. Hemostatic drugs (procoagulant medications) are primarily used in trauma and surgeries with significant bleeding but can also be used in obstetric bleeding, pathological bleeding due to coagulation disorders, or in…
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Overview of Blood Components and Hemostatic Drugs

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Production of Blood Components Whole blood collected in CPD anticoagulant is processed by either the B1 or B2 method (Figure 1 below). In the B1 method, whole blood is centrifuged to separate the red blood cells from the platelets and plasma. The red blood cells are then leukoreduced (LR) by…
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Thoracic Anesthesia in Cardiac and Pulmonary Surgery

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Cardiothoracic Anesthesia Coronary bypass (CABG) performed in the hospital's operating room for treating heart diseases caused by ischemic coronary artery disease Cardiac Chambers and Valves Aortic Valve Pressure: 120/70 mmHg Valve area: 2.5–3.5 cm² Mitral Valve Valve area: 4–6 cm² Pulmonic Valve Pressure: 25/10 mmHg Valve area: 2 cm² Right…
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Circulatory Failure and Inotropic Drugs – Diagnosis and Treatment

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Circulatory Failure and Blood Pressure Raising Treatment Inotropic treatment refers to intravenous vasopressor treatment with potent short-acting vasoactive drugs. The commonly used drugs are synthetic fast-acting catecholamines. These medications are administered intravenously, either intermittently or continuously, via a central venous catheter (CVC) or a peripheral venous cannula (PVC). The treatment…
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Nerve Blocks and Neuraxial Anesthesia – Regional Techniques

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Adductor Canal Block/Subsartorius Block Indication: Blockade of the saphenus nerve - nervus saphenus . Surgery involving saphenous vein stripping. Adjuvant in medial foot/ankle surgery combined with sciatic nerve block and analgesia for knee surgery combined with other pain relief. Provides anesthesia on the medial side of the leg. https://youtu.be/MfdaL95f7mc Technique:…
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Local Anesthetic Drugs – Safe Use, Toxicity and Maximum Doses

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Local Anesthetics Local anesthetics are used to anaesthetize areas of the body to perform surgical procedures, painful examinations, or simply to provide pain relief. Local anesthetics are pharmacologically divided into two groups; amino esters and amino amides. Esters generally have higher toxicity than amino amides, and most of the preparations…
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